He has a nasty trauma AE that you'll want to have scouts joust most likely. Squishy people should just stay away period. Important! Before you start, set loot to Free For All. Crucial!
We position the raid right in the doorway to begin, with the MT taking the mob to the corner to the right. Healers will have to adjust, but the mob itself doesn't really hit all that hard.
When the fight begins, Ozyk chooses four people in the raid (seems random) and those four people will start taking damage similar to a Lifeburn. This will NOT stop for the entire fight. Even if you rez them, the effect is re-applied. You simply have to heal them up and keep healing them. Druids are great for this sort of thing. Keep healing!
Periodically during the fight, adds will spawn in the room. I believe they are called Void Sappers. Have your off tank waiting for this spawn. The adds have NOTHING for HP, hit like pansies and are linked. SK / Pally / Zerker ideal for this. Have a couple good AE classes using the Offtank as their assist. Burn the adds down as they come in. As the adds die, LOOT THE CORPSES. The corpses have bombs on them, that if not looted, explode and damage people nearby. If looted, the bombs do nothing.
Joust the trauma, burn and loot the adds, keep the four selected targets alive. Loot chest. It's really that simple.